Antisense phosphorothioates as antivirals against human immunodeficiency virus (HIV) and hepatitis B virus (HBV)
Identifieur interne : 004103 ( Main/Exploration ); précédent : 004102; suivant : 004104Antisense phosphorothioates as antivirals against human immunodeficiency virus (HIV) and hepatitis B virus (HBV)
Auteurs : Makoto Matsukura [Japon] ; Kazuo Koike [Japon] ; Gerald Zon [États-Unis]Source :
- Toxicology Letters [ 0378-4274 ] ; 1995.
English descriptors
- Teeft :
- Animal models, Antisense, Antisense activity, Assay, Assay systems, Base composition, Cell line, Complete medium, Cytopathic, Cytopathic effect inhibition assay, Cytotoxicity, Gene expression, Human immunodeficiency virus, Immunodeficiency, Initiation site, Matsukura, Oligodeoxynucleotides, Oligomers, Phosphorothioate, Phosphorothioate oligodeoxynucleotides, Toxicity, Toxicology, Transgenic, Transgenic mice, Viral, Viral expression, Viral gene expression assay, Viral gene expression inhibition assay, Vivo experiments.
Abstract
Abstract: For the past 10 years we have focused on the development of antisense treatments against viral infections such as human immunodeficiency virus (HIV) and hepatitis B virus (HBV). We have demonstrated that phosphorothioate oligomers have in vitro anti-HIV activities and in vivo anti-HBV activity. In vitro anti-HIV activities of phosphorothioate oligodeoxynucleotides (S-oligo) were classified into sequence non-specific (non-antisense) and sequence specific (antisense). We found that toxicity of S-oligo could be also classified into the same 2 categories. Since some of non-specific toxicity is dependent on experimental conditions, in each experiment, we should pay attention to minimize non-specific toxicity of the oligomers.
Url:
DOI: 10.1016/0378-4274(95)03574-5
Affiliations:
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We have demonstrated that phosphorothioate oligomers have in vitro anti-HIV activities and in vivo anti-HBV activity. In vitro anti-HIV activities of phosphorothioate oligodeoxynucleotides (S-oligo) were classified into sequence non-specific (non-antisense) and sequence specific (antisense). We found that toxicity of S-oligo could be also classified into the same 2 categories. 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